Khaled Moussawi, MD, PhD

Assoc Professor in Residence

Departments of Neurology and Psychiatry

The Translational Neuropsychiatry Through Neuromodulaton (TN²) laboratory investigates the neurobiology of substance use disorders and uses neuromodulation tools such as Low-Intensity Focused Ultrasound (LIFU), Transcranial Magnetic Stimulation (TMS), and Deep Brain Stimulation (DBS) to treat drug and alcohol addiction and related neuropsychiatric disorders. The goal of the lab is to identify neural biomarkers of craving and drug-seeking behaviors and leverage those findings to develop individualized clinical treatments with neuromodulation.

Publications

Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration.

Psychopharmacology

Pachenari N, Channell AL, Belilos AJ, Dienel SJ, Moussawi K

Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease.

Brain stimulation

Abiola OA, Lehmann C, Moussawi K, Jalal H

Generalized cue reactivity in rat dopamine neurons after opioids.

Nature communications

Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K

Associations of Mild Behavioral Impairment Domains with Brain Volumes in Older Adults.

Journal of the Academy of Consultation-Liaison Psychiatry

Young L, Richey LN, Law CA, Esagoff AI, Ismail Z, Senjem ML, Jack CR, Shrestha S, Gottesman RF, Moussawi K, Peters ME, Schneider ALC

Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.

Brain sciences

Keihani A, Sanguineti C, Chaichian O, Huston CA, Moore C, Cheng C, Janssen SA, Donati FL, Mayeli A, Moussawi K, Phillips ML, Ferrarelli F

Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease.

medRxiv : the preprint server for health sciences

Abiola OA, Lehmann C, Moussawi K, Jalal H

Generalized cue reactivity in dopamine neurons after opioids.

bioRxiv : the preprint server for biology

Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K

Opioid modulation of prefrontal cortex cells and circuits.

Neuropharmacology

Cole RH, Moussawi K, Joffe ME

Stable, neuron-specific gene expression in the mouse brain.

Journal of biological engineering

Ahmed O, Ekumi KM, Nardi FV, Maisumu G, Moussawi K, Lazartigues ED, Liang B, Yakoub AM

Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment.

The American journal of psychiatry

Soleimani G, Joutsa J, Moussawi K, Siddiqi SH, Kuplicki R, Bikson M, Paulus MP, Fox MD, Hanlon CA, Ekhtiari H

Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Lehmann CM, Moussawi K

Brain lesions disrupting addiction map to a common human brain circuit.

Nature medicine

Joutsa J, Moussawi K, Siddiqi SH, Abdolahi A, Drew W, Cohen AL, Ross TJ, Deshpande HU, Wang HZ, Bruss J, Stein EA, Volkow ND, Grafman JH, van Wijngaarden E, Boes AD, Fox MD

Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease.

Brain stimulation

Moussawi K, Kim MJ, Baybayan S, Wood M, Mills KA

Operant Vapor Self-administration in Mice.

Bio-protocol

Marchette RCN, Tunstall BJ, Vendruscolo LF, Moussawi K

Excitation of medium spiny neurons by 'inhibitory' ultrapotent chemogenetics via shifts in chloride reversal potential.

eLife

Gantz SC, Ortiz MM, Belilos AJ, Moussawi K

A 33-Year-Old Man with Progressive Diffuse and Focal Neuropsychiatric Signs without Localizing Correlates on Brain Imaging: A Systematic Approach to Diagnosis.

Journal of psychiatry and psychiatric disorders

Moussawi K, Gholipour T, Rao V

Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.

The Journal of pharmacology and experimental therapeutics

Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE

Khaled Moussawi, MD, PhD

Publications

Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration.

Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease.

Generalized cue reactivity in rat dopamine neurons after opioids.

Associations of Mild Behavioral Impairment Domains with Brain Volumes in Older Adults.

Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.

Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease.

Generalized cue reactivity in dopamine neurons after opioids.

Opioid modulation of prefrontal cortex cells and circuits.

Stable, neuron-specific gene expression in the mouse brain.

Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment.

Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse.

Brain lesions disrupting addiction map to a common human brain circuit.

Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease.

Operant Vapor Self-administration in Mice.

Excitation of medium spiny neurons by 'inhibitory' ultrapotent chemogenetics via shifts in chloride reversal potential.

A 33-Year-Old Man with Progressive Diffuse and Focal Neuropsychiatric Signs without Localizing Correlates on Brain Imaging: A Systematic Approach to Diagnosis.

Fentanyl vapor self-administration model in mice to study opioid addiction.

Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons.

Paraneoplastic PRES from lymphoma induced hypercalcemia: Case report and review of the literature.

Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine.

Report of transient events in a cocaine-dependent volunteer who received iTBS.

Teaching Clinical Reasoning with an Example Mnemonic for the Neuropsychiatric Syndromes of Traumatic Brain Injury.

Intracranial Tuberculoma in a Patient With Untreated Human Immunodeficiency Virus.

Clinical Reasoning: A 20-year-old man with headache and double vision.

Abstinence From Drug Dependence After Bilateral Globus Pallidus Hypoxic-Ischemic Injury.

Brainstem and limbic encephalitis with paraneoplastic neuromyelitis optica.

Optogenetic inhibition of cocaine seeking in rats.

Role of mGluR5 neurotransmission in reinstated cocaine-seeking.

The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.

Extracellular glutamate: functional compartments operate in different concentration ranges.

Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.

Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.

Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.

Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.

Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction.

Altered dendritic spine plasticity in cocaine-withdrawn rats.

N-Acetylcysteine reverses cocaine-induced metaplasticity.