Khaled Moussawi, MD, PhD

Assoc Professor in Residence
Departments of Neurology and Psychiatry
[email protected]

The Translational Neuropsychiatry Through Neuromodulaton (TN²) laboratory investigates the neurobiology of substance use disorders and uses neuromodulation tools such as Low-Intensity Focused Ultrasound (LIFU), Transcranial Magnetic Stimulation (TMS), and Deep Brain Stimulation (DBS) to treat drug and alcohol addiction and related neuropsychiatric disorders. The goal of the lab is to identify neural biomarkers of craving and drug-seeking behaviors and leverage those findings to develop individualized clinical treatments with neuromodulation.

Publications: 

Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration.

Psychopharmacology

Pachenari N, Channell AL, Belilos AJ, Dienel SJ, Moussawi K

Generalized cue reactivity in rat dopamine neurons after opioids.

Nature communications

Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K

Associations of Mild Behavioral Impairment Domains with Brain Volumes in Older Adults.

Journal of the Academy of Consultation-Liaison Psychiatry

Young L, Richey LN, Law CA, Esagoff AI, Ismail Z, Senjem ML, Jack CR, Shrestha S, Gottesman RF, Moussawi K, Peters ME, Schneider ALC

Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.

Brain sciences

Keihani A, Sanguineti C, Chaichian O, Huston CA, Moore C, Cheng C, Janssen SA, Donati FL, Mayeli A, Moussawi K, Phillips ML, Ferrarelli F

Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease.

medRxiv : the preprint server for health sciences

Abiola OA, Lehmann C, Moussawi K, Jalal H

Generalized cue reactivity in dopamine neurons after opioids.

bioRxiv : the preprint server for biology

Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K

Opioid modulation of prefrontal cortex cells and circuits.

Neuropharmacology

Cole RH, Moussawi K, Joffe ME

Stable, neuron-specific gene expression in the mouse brain.

Journal of biological engineering

Ahmed O, Ekumi KM, Nardi FV, Maisumu G, Moussawi K, Lazartigues ED, Liang B, Yakoub AM

Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment.

The American journal of psychiatry

Soleimani G, Joutsa J, Moussawi K, Siddiqi SH, Kuplicki R, Bikson M, Paulus MP, Fox MD, Hanlon CA, Ekhtiari H

Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Lehmann CM, Moussawi K

Brain lesions disrupting addiction map to a common human brain circuit.

Nature medicine

Joutsa J, Moussawi K, Siddiqi SH, Abdolahi A, Drew W, Cohen AL, Ross TJ, Deshpande HU, Wang HZ, Bruss J, Stein EA, Volkow ND, Grafman JH, van Wijngaarden E, Boes AD, Fox MD

Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease.

Brain stimulation

Moussawi K, Kim MJ, Baybayan S, Wood M, Mills KA

Operant Vapor Self-administration in Mice.

Bio-protocol

Marchette RCN, Tunstall BJ, Vendruscolo LF, Moussawi K

Fentanyl vapor self-administration model in mice to study opioid addiction.

Science advances

Moussawi K, Ortiz MM, Gantz SC, Tunstall BJ, Marchette RCN, Bonci A, Koob GF, Vendruscolo LF

Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine.

Current opinion in neurobiology

Francis TC, Gantz SC, Moussawi K, Bonci A

Report of transient events in a cocaine-dependent volunteer who received iTBS.

Brain stimulation

Steele VR, Maxwell AM, Ross TJ, Moussawi K, Abulseoud OO, Stein EA, Salmeron BJ

Teaching Clinical Reasoning with an Example Mnemonic for the Neuropsychiatric Syndromes of Traumatic Brain Injury.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

Peters ME, Moussawi K, Rao V

Brainstem and limbic encephalitis with paraneoplastic neuromyelitis optica.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Moussawi K, Lin DJ, Matiello M, Chew S, Morganstern D, Vaitkevicius H

Optogenetic inhibition of cocaine seeking in rats.

Addiction biology

Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, Deisseroth K, Kalivas PW, LaLumiere RT

Role of mGluR5 neurotransmission in reinstated cocaine-seeking.

Addiction biology

Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW

The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.

Biological psychiatry

Kupchik YM, Moussawi K, Tang XC, Wang X, Kalivas BC, Kolokithas R, Ogburn KB, Kalivas PW

Extracellular glutamate: functional compartments operate in different concentration ranges.

Frontiers in systems neuroscience

Moussawi K, Riegel A, Nair S, Kalivas PW

Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.

Proceedings of the National Academy of Sciences of the United States of America

Shen H, Moussawi K, Zhou W, Toda S, Kalivas PW

Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.

The Journal of pharmacology and experimental therapeutics

Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE

Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.

Proceedings of the National Academy of Sciences of the United States of America

Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB, Kalivas PW

Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Knackstedt LA, Moussawi K, Lalumiere R, Schwendt M, Klugmann M, Kalivas PW

Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction.

European journal of pharmacology

Moussawi K, Kalivas PW

Altered dendritic spine plasticity in cocaine-withdrawn rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Shen HW, Toda S, Moussawi K, Bouknight A, Zahm DS, Kalivas PW

N-Acetylcysteine reverses cocaine-induced metaplasticity.

Nature neuroscience

Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW